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Article

Effects of rs6234/rs6235 and rs6232/rs6234/rs6235 PCSK1 single-nucleotide polymorphism clusters on proprotein convertase 1/3 biosynthesis and activity.

Molecular genetics and metabolism - 1 Dec 2011

Mbikay Majambu, Sirois Francine, Nkongolo Kabwe K, Basak Ajoy, Chrétien Michel

Abstract excerpt

BACKGROUND: Proprotein convertase 1/3 (PC1/3) is one of the endoproteases initiating the proteolytic activation of prohormones and proneuropeptides in the secretory pathway. It is produced as a zymogen that is subsequently modified by activity-determining cleavages at the amino and the carboxyl t...

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Source

Identifiers

PMID: 22000902
DOI: 10.1016/j.ymgme.2011.09.027

Genes

PCSK1
POMC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-22000902-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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