Article
Polymorphisms in one-carbon metabolism pathway genes, urinary arsenic profile, and urothelial carcinoma.
Cancer causes & control : CCC - 1 Oct 2010
Chung Chi-Jung, Pu Yeong-Shiau, Su Chien-Tien, Chen Hui-Wen, Huang Yung-Kai, Shiue Horng-Sheng, Hsueh Yu-Mei
Abstract excerpt
BACKGROUND: Gene polymorphisms in the one-carbon metabolism pathway could contribute to arsenic methylation capability through plasma folate and homocysteine metabolism, thereby increasing the susceptibility to urothelial carcinoma (UC) risk. OBJECTIVES: The goal of our study was to evaluate the roles of gene polymorphisms in the one-carbon metabolism pathway in the carcinogenesis of UC. METHODS: A hospital-based...
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