Article
Serum homocysteine, arsenic methylation, and arsenic-induced skin lesion incidence in Bangladesh: A one-carbon metabolism candidate gene study.
Environment international - 1 Apr 2018
Niedzwiecki Megan M, Liu Xinhua, Zhu Huiping, Hall Megan N, Slavkovich Vesna, Ilievski Vesna, Levy Diane, Siddique Abu B, Kibriya Muhammad G, Parvez Faruque, Islam Tariqul, Ahmed Alauddin, Navas-Acien Ana, Graziano Joseph H, Finnell Richard H, Ahsan Habibul, Gamble Mary V
Abstract excerpt
BACKGROUND: Inorganic arsenic (As) is methylated via one carbon metabolism (OCM) to mono- and dimethylated arsenicals (MMA and DMA), facilitating urinary excretion. Hyperhomocysteinemia (HHcys), a marker of impaired OCM, is a risk factor for As-induced skin lesions, but the influences of single nucleotide polymorphisms (SNPs) in OCM genes on Hcys, As metabolism and skin lesion risk is unclear. OBJECTIVES: To (i)...
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