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Article

Mutant huntingtin-impaired degradation of beta-catenin causes neurotoxicity in Huntington's disease.

The EMBO journal - 21 Jul 2010

Godin Juliette D, Poizat Ghislaine, Hickey Miriam A, Maschat Florence, Humbert Sandrine

Abstract excerpt

Huntington's disease (HD) is a fatal neurodegenerative disorder causing selective neuronal death in the brain. Dysfunction of the ubiquitin-proteasome system may contribute to the disease; however, the exact mechanisms are still unknown. We report here a new pathological mechanism by which mutant huntingtin specifically interferes with the degradation of beta-catenin. Huntingtin associates with the beta-catenin...

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Identifiers

PMID: 20531388
DOI: 10.1038/emboj.2010.117
PMCID: PMC2910267

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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