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Article

Inhibition of Rho kinases enhances the degradation of mutant huntingtin.

The Journal of biological chemistry - 8 May 2009

Bauer Peter O, Wong Hon Kit, Oyama Fumitaka, Goswami Anand, Okuno Misako, Kino Yoshihiro, Miyazaki Haruko, Nukina Nobuyuki

Abstract excerpt

Huntington disease (HD) is a fatal hereditary neurodegenerative disease caused by an expansion of the polyglutamine (polyQ) stretch in huntingtin (htt). Whereas the pathological significance of the expanded polyQ has been clearly established and a tremendous effort to develop therapeutic tools for HD has been exerted, there is yet no effective cure. Whereas many molecules able to reduce the polyQ accumulation and...

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Source

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Identifiers

PMID: 19278999
DOI: 10.1074/jbc.M809229200
PMCID: PMC2676047

Genes

ROCK1
ROCK2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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