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Article

Gastrodin Improves the Activity of the Ubiquitin-Proteasome System and the Autophagy-Lysosome Pathway to Degrade Mutant Huntingtin.

International journal of molecular sciences - 14 Jul 2024

Sun He, Li Miao, Li Yunling, Zheng Na, Li Jiaxin, Li Xiang, Liu Yingying, Ji Qianyun, Zhou Liping, Su Jingwen, Huang Wanxu, Liu Zhongbo, Liu Peng, Zou Libo

Abstract excerpt

Gastrodin (GAS) is the main chemical component of the traditional Chinese herb Gastrodia elata (called "Tianma" in Chinese), which has been used to treat neurological conditions, including headaches, epilepsy, stroke, and memory loss. To our knowledge, it is unclear whether GAS has a therapeutic effect on Huntington's disease (HD). In the present study, we evaluated the effect of GAS on the degradation of mutant...

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PMID: 39062952
DOI: 10.3390/ijms25147709
PMCID: PMC11277377

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