Article
Extremely slow metabolism of amitriptyline but normal metabolism of imipramine and desipramine in an extensive metabolizer of sparteine, debrisoquine, and mephenytoin.
Therapeutic drug monitoring - 1 Mar 1991
Brøsen K, Gram L F, Kragh-Sørensen P
Abstract excerpt
A 34-year-old man with bipolar manic depressive illness suffered from severe adverse effects during treatment with amitriptyline, 50 mg/day. It was subsequently shown that the patient was a slow metabolizer of amitriptyline. However, he tolerated a dose of 200 mg of imipramine/day, which was nece...
Topics
- Administration, Oral
- Adult
- Amitriptyline
- Antidepressive Agents, Tricyclic
- Chromatography, Thin Layer
- Debrisoquin
- Desipramine
- Drug Interactions
- Humans
- Imipramine
- Male
- Mephenytoin
- Phenotype
- Quinidine
- Sparteine