Article
Comparative effects of the diastereoisomers, quinine and quinidine in producing phenocopy debrisoquine poor metabolisers (PMs) in healthy volunteers.
Chirality - 1 Jan 1991
Ayesh R, Dawling S, Hayler A, Oates N S, Cholerton S, Widdop B, Idle J R, Smith R L
Abstract excerpt
1. A single oral dose (50 mg) of quinidine significantly increased the debrisoquine metabolic ratio in six healthy volunteers. For four of the volunteers the metabolic ratio changed to that typical of the poor metaboliser (PM) phenotype. 2. The effect of quinidine in producing debrisoquine oxidation "poor metaboliser" phenocopies persisted for at least 3 days but had disappeared by 1 week. 3. The debrisoquine...
Topics
- Adult
- Debrisoquin
- Desipramine
- Female
- Humans
- Male
- Metabolic Clearance Rate
- Molecular Structure
- Nortriptyline
- Phenotype
- Quinidine