The mephenytoin oxidation polymorphism is partially responsible for the N-demethylation of imipramine.

doi:10.1038/clpt.1991.4

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Article

The mephenytoin oxidation polymorphism is partially responsible for the N-demethylation of imipramine.

Clinical pharmacology and therapeutics - 1 Jan 1991

Skjelbo E, Brøsen K, Hallas J, Gram L F

Abstract excerpt

The metabolism of imipramine in six poor metabolizers of mephenytoin was compared with the metabolism of 16 extensive metabolizers of mephenytoin from an earlier study. Each subject was given single doses of 100 mg imipramine hydrochloride and 100 mg desipramine hydrochloride on separate occasion...

Topics

Adult
Cytochrome P-450 Enzyme System
Desipramine
Female
Humans
Imipramine
Isoenzymes
Male
Mephenytoin
Methylation
Microsomes, Liver
Oxidation-Reduction
Phenotype
Polymorphism, Genetic

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