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Article

The mephenytoin oxidation polymorphism is partially responsible for the N-demethylation of imipramine.

Clinical pharmacology and therapeutics - 1 Jan 1991

Skjelbo E, Brøsen K, Hallas J, Gram L F

Abstract excerpt

The metabolism of imipramine in six poor metabolizers of mephenytoin was compared with the metabolism of 16 extensive metabolizers of mephenytoin from an earlier study. Each subject was given single doses of 100 mg imipramine hydrochloride and 100 mg desipramine hydrochloride on separate occasions. Imipramine demethylation clearance was 0.74 L.min-1 (mean; range, 0.31-1.24) in poor metabolizers of mephenytoin...

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Share to Cytochrome P-450 Enzyme System
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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Share to Microsomes, Liver

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Share to Polymorphism, Genetic

Source

Identifiers

PMID: 1988236
DOI: 10.1038/clpt.1991.4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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