Article
Clinical consequences of polymorphic drug oxidation.
Fundamental & clinical pharmacology - 1 Jan 1991
Alván G
Abstract excerpt
Many characters are genetically regulated as polymorphisms. This means that discrete groups are seen within the distribution of a certain character. Drug metabolism is no exception and the polymorphism of acetylation is recognised since the 50's. Polymorphic drug oxidation was discovered in the 70's and has been extensively studied. There are two fully established polymorphisms in drug oxidation named as the...
Topics
- Debrisoquin
- Humans
- Oxidation-Reduction
- Pharmaceutical Preparations
- Phenotype
- Polymorphism, Genetic
