Article
Extremely long plasma half-life of amitriptyline in a woman with the cytochrome P450IID6 29/29-kilobase wild-type allele--a slowly reversible interaction with fluoxetine.
Therapeutic drug monitoring - 1 Nov 1991
Müller N, Brockmöller J, Roots I
Abstract excerpt
A 61-year-old woman, a nonsmoker, was admitted to the hospital because of endogenous depression. No concomitant disease, especially kidney or liver dysfunction, was diagnosed. After 9 days of treatment with 125 mg of amitriptyline (AMI) daily, she developed signs of a severe anticholinergic syndr...
Topics
- Alleles
- Amitriptyline
- Chromatography, High Pressure Liquid
- Cytochrome P-450 Enzyme System
- Debrisoquin
- Depression
- Drug Interactions
- Female
- Fluoxetine
- Fluvoxamine
- Half-Life
- Humans
- Middle Aged
- Nortriptyline
- Phenotype
- Spectrophotometry, Ultraviolet