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Article

Imipramine metabolism in relation to the sparteine oxidation polymorphism--a family study.

Pharmacogenetics - 1 Dec 1996

Madsen H, Hansen T S, Brøsen K

Abstract excerpt

The relationship between genetic polymorphism and imipramine metabolism has never been studied in a family study. A sparteine/mephenytoin test was carried out in 31 parents and 20 siblings of 18 Danish poor metabolizers of sparteine (PMs). One week later, each subject took 25 mg imipramine followed by urine collection for 24 h. The urinary content of imipramine, desipramine, 2-hydroxy-imipramine and...

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Source

Identifiers

PMID: 9014200
DOI: 10.1097/00008571-199612000-00004

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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