Imipramine metabolism in relation to the sparteine oxidation polymorphism--a family study.

doi:10.1097/00008571-199612000-00004

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Article

Imipramine metabolism in relation to the sparteine oxidation polymorphism--a family study.

Pharmacogenetics - 1 Dec 1996

Madsen H, Hansen T S, Brøsen K

Abstract excerpt

The relationship between genetic polymorphism and imipramine metabolism has never been studied in a family study. A sparteine/mephenytoin test was carried out in 31 parents and 20 siblings of 18 Danish poor metabolizers of sparteine (PMs). One week later, each subject took 25 mg imipramine follow...

Topics

Adolescent
Adult
Cytochrome P-450 CYP2D6
Female
Genotype
Heterozygote
Homozygote
Humans
Imipramine
Male
Middle Aged
Nuclear Family
Pedigree
Phenotype
Polymorphism, Genetic
Sparteine

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