Article
Steady state concentrations of the enantiomers of mianserin and desmethylmianserin in poor and in homozygous and heterozygous extensive metabolizers of debrisoquine.
Therapeutic drug monitoring - 1 Feb 1998
Eap C B, Lima C A, Macciardi F, Woggon B, Powell K, Baumann P
Abstract excerpt
Steady state concentrations of (S)- and (R)-mianserin and desmethylmianserin were measured in 21 homozygous extensive metabolizers (as determined by genotyping for mutations 3 [or A] and 4 [or B]), in seven heterozygous extensive metabolizers and in one poor metabolizer of debrisoquine, as well a...
Topics
- Adult
- Aged
- Aged, 80 and over
- Antidepressive Agents, Second-Generation
- Antihypertensive Agents
- Cytochrome P-450 CYP2D6
- Debrisoquin
- Female
- Genotype
- Humans
- Isomerism
- Male
- Mianserin
- Middle Aged
- White People