Article
[Pharmacogenetics of antidepressant metabolism. Value of the debrisoquin test].
L'Encephale - 1 Jan 2000
Baumann P
Abstract excerpt
The drug monitoring of antidepressants in blood plasma has revealed considerable interindividual differences in steady-state levels. For some compounds recent results strongly suggest that this phenomenon finds an explanation in genetic differences in the metabolism of the drugs by monooxygenases (cytochrome P-450) in the liver. Thus, a genetic deficiency has been described in 5-10% of the European population in...
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