Article
[Pharmacogenetics of antidepressant metabolism. Value of the debrisoquin test].
L'Encephale - 1 Jan 2000
Baumann P
Abstract excerpt
The drug monitoring of antidepressants in blood plasma has revealed considerable interindividual differences in steady-state levels. For some compounds recent results strongly suggest that this phenomenon finds an explanation in genetic differences in the metabolism of the drugs by monooxygenases...
Topics
- Adult
- Aged
- Aged, 80 and over
- Antidepressive Agents
- Cytochrome P-450 Enzyme System
- Debrisoquin
- Depressive Disorder
- Female
- Humans
- Hydroxylation
- Isoquinolines
- Male
- Middle Aged
- Pharmacogenetics
- Phenotype
- Polymorphism, Genetic