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Article

DNAJB6 induces degradation of beta-catenin and causes partial reversal of mesenchymal phenotype.

The Journal of biological chemistry - 6 Aug 2010

Mitra Aparna, Menezes Mitchell E, Shevde Lalita A, Samant Rajeev S

Abstract excerpt

We showed that expression of MRJ (DNAJB6) protein is lost in invasive ductal carcinoma, and restoration of MRJ(L) restricts malignant behavior of breast cancer and melanoma cells. However, the signaling pathways influenced by MRJ(L) are largely unknown. Our observations revealed that MRJ(L) expression causes changes in cell morphology concomitant with down-regulation of several mesenchymal markers, viz. vimentin,...

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Identifiers

PMID: 20522561
DOI: 10.1074/jbc.M109.094847
PMCID: PMC2915705

Genes

DNAJB6
DKK1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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