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Article

Monoubiquitination of p120-catenin is essential for TGFβ-induced epithelial-mesenchymal transition and tumor metastasis

22 Jan 2020

Abstract excerpt

Disassembly of intercellular junctions is a hallmark of epithelial-mesenchymal transition (EMT). However, how the junctions disassemble remains largely unknown. Here, we report that E3 ubiquitin ligase Smurf1 targets p120-catenin, a core component of adherens junction (AJ) complex, for monoubiquitination during transforming growth factor β (TGFβ)-induced EMT, thereby leading to AJ dissociation. Upon TGFβ...

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Share to Cancer Cells and Metastasis
Share to TGF-β signaling in diseases
Share to Wnt/β-catenin signaling in development and cancer

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PMID: 32010791
DOI: 10.1126/sciadv.aay9819

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