Article
Review: personalized mice: modelling the molecular heterogeneity of medulloblastoma.
Neuropathology and applied neurobiology - 1 Jun 2012
Markant S L, Wechsler-Reya R J
Abstract excerpt
Medulloblastoma, the most common malignant paediatric brain tumour, is thought to arise from mutations in progenitors or stem cells in the cerebellum. Recent molecular analyses have highlighted the heterogeneity of these tumours, and demonstrated that they can be classified into at least four major subtypes that differ in terms of gene expression, genomic gains and losses, epidemiology and patient outcome. Along...
Topics
- Animals
- Brain Neoplasms
- Disease Models, Animal
- Humans
- Medulloblastoma
- Mice
- Mutation
- Signal Transduction
- Stem Cells