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Article

PTEN Loss Mitigates the Response of Medulloblastoma to Hedgehog Pathway Inhibition

24 Oct 2013

Abstract excerpt

Medulloblastoma is a cancer of the cerebellum, for which there is currently no approved targeted therapy. Recent transcriptomics approaches have demonstrated that medulloblastoma is composed of molecularly distinct subgroups, one of which is characterized by activation of the Hedgehog pathway, which in mouse models is sufficient to drive medulloblastoma development. There is thus considerable interest in...

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PMID: 24154871
DOI: 10.1158/0008-5472.can-13-1222

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