MiR-34a deficiency accelerates medulloblastoma formation in vivo.

doi:10.1002/ijc.29294

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Article

MiR-34a deficiency accelerates medulloblastoma formation in vivo.

International journal of cancer - 15 May 2015

Thor Theresa, Künkele Annette, Pajtler Kristian W, Wefers Annika K, Stephan Harald, Mestdagh Pieter, Heukamp Lukas, Hartmann Wolfgang, Vandesompele Jo, Sadowski Natalie, Becker Lore, Garrett Lillian, Hölter Sabine M, Horsch Marion, Calzada-Wack Julia, Klein-Rodewald Tanja, Racz Ildiko, Zimmer Andreas, Beckers Johannes, Neff Frauke, Klopstock Thomas, De Antonellis Pasqualino, Zollo Massimo, Wurst Wolfgang, Fuchs Helmut, Gailus-Durner Valérie, Schüller Ulrich, de Angelis Martin Hrabě, Eggert Angelika, Schramm Alexander, Schulte Johannes H

Abstract excerpt

Previous studies have evaluated the role of miRNAs in cancer initiation and progression. MiR-34a was found to be downregulated in several tumors, including medulloblastomas. Here we employed targeted transgenesis to analyze the function of miR-34a in vivo. We generated mice with a constitutive deletion of the miR-34a gene. These mice were devoid of mir-34a expression in all analyzed tissues, but were viable and...

Topics

Animals
Cell Line, Tumor
Cell Proliferation
Cerebellar Neoplasms
Cerebellum
Gene Expression Regulation, Neoplastic
Gene Knockout Techniques

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Humans

Medulloblastoma

Mice

Mice, Transgenic

MicroRNAs

Phenotype

Signal Transduction

Source

Open in PubMed

Identifiers

PMID: 25348795
DOI: 10.1002/ijc.29294

Genes

MYCN
SIRT1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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