Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Crucial role of p53-dependent cellular senescence in suppression of Pten-deficient tumorigenesis.

Nature - 4 Aug 2005

Chen Zhenbang, Trotman Lloyd C, Shaffer David, Lin Hui-Kuan, Dotan Zohar A, Niki Masaru, Koutcher Jason A, Scher Howard I, Ludwig Thomas, Gerald William, Cordon-Cardo Carlos, Pandolfi Pier Paolo

Abstract excerpt

Cellular senescence has been theorized to oppose neoplastic transformation triggered by activation of oncogenic pathways in vitro, but the relevance of senescence in vivo has not been established. The PTEN and p53 tumour suppressors are among the most commonly inactivated or mutated genes in human cancer including prostate cancer. Although they are functionally distinct, reciprocal cooperation has been proposed,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to ADP-Ribosylation Factors
Share to Cell Transformation, Neoplastic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cellular Senescence

Share to Phosphoric Monoester Hydrolases

Share to Prostatic Neoplasms

Share to PTEN Phosphohydrolase

Share to Survival Analysis

Share to Tumor Suppressor Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 16079851
DOI: 10.1038/nature03918
PMCID: PMC1939938

Genes

PTEN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Crucial role of p53-dependent cellular senescence in suppression of Pten-deficient tumorigenesis.PMID 16079851Read ↗

A novel type of cellular senescence that can be enhanced in mouse models and human tumor xenografts to suppress prostate tumorigenesisSemantic proximity Read ↗

PTEN deletion in luminal cells of mature prostate induces replication stress and senescence in vivo.Semantic proximity Read ↗

Vulnerabilities of <i>PTEN</i> – <i>TP53</i> -Deficient Prostate Cancers to Compound PARP–PI3K InhibitionSemantic proximity Read ↗

A Dominant Role for p53-Dependent Cellular Senescence in Radiosensitization of Human Prostate Cancer CellsSemantic proximity Read ↗

Tumour suppression by p53: the importance of apoptosis and cellular senescence.Semantic proximity Read ↗

Identification of PHLPP1 as a tumor suppressor reveals the role of feedback activation in PTEN-mutant prostate cancer progression.Semantic proximity Read ↗

<i>Pten</i> Deficiency Activates Distinct Downstream Signaling Pathways in a Tissue-Specific MannerSemantic proximity Read ↗

Differential p53-Independent Outcomes of p19 Arf Loss in OncogenesisSemantic proximity Read ↗

Targeted biallelic inactivation of Pten in the mouse prostate leads to prostate cancer accompanied by increased epithelial cell proliferation but not by reduced apoptosis.Semantic proximity Read ↗

Locally-invasive, castrate-resistant prostate cancer in a Pten/Trp53 double knockout mouse model of prostate cancer monitored with non-invasive bioluminescent imagingSemantic proximity Read ↗

Senescence in pancreatic carcinogenesis: from signalling to chromatin remodelling and epigenetics.Semantic proximity Read ↗

Polo-like Kinase 1 Facilitates Loss of Pten Tumor Suppressor-induced Prostate Cancer FormationSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.