Article
Naturally occurring MHR variants in Turkish patients infected with hepatitis B virus.
Journal of medical virology - 1 Mar 2008
Sayiner A Arzu, Ozcan Ayla, Sengonul Aylin
Abstract excerpt
Major B-cell epitopes are located at the major hydrophilic region (MHR) of hepatitis B virus (HBV) surface antigen (HBsAg). The genotypes, subtypes, and naturally occurring amino acid (aa) substitutions of MHR were analyzed in 81 Turkish adult patients (41 inactive HBsAg carriers and 40 patients with chronic hepatitis B) by direct sequencing of the S gene fragment. All the isolates were genotype D according to...
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