Article
Receptor and betagamma binding sites in the alpha subunit of the retinal G protein transducin.
Science (New York, N.Y.) - 17 Jan 1997
Onrust R, Herzmark P, Chi P, Garcia P D, Lichtarge O, Kingsley C, Bourne H R
Abstract excerpt
Transmembrane receptors for hormones, neurotransmitters, light, and odorants mediate their cellular effects by activating heterotrimeric guanine nucleotide-binding proteins (G proteins). Crystal structures have revealed contact surfaces between G protein subunits, but not the surfaces or molecular mechanism through which Galphabetagamma responds to activation by transmembrane receptors. Such a surface was...
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