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Centrosome-related genes, genetic variation, and risk of breast cancer.

Breast cancer research and treatment - 1 Jan 2011

Olson J E, Wang X, Pankratz V S, Fredericksen Z S, Vachon C M, Vierkant R A, Cerhan J R, Couch F J

Abstract excerpt

Centrosome amplification has been detected in premalignant lesions and in situ tumors in the breast and in over 70% of invasive breast tumors, and has been associated with aneuploidy and tumor development. Based on these observations, the contribution of commonly inherited genetic variation in candidate genes related to centrosome structure and function to breast cancer risk was evaluated in an association study....

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PMID: 20508983
DOI: 10.1007/s10549-010-0950-8
PMCID: PMC2997159

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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