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Prognostic value of CA20, a score based on centrosome amplification-associated genes, in breast tumors

15 Mar 2017

Abstract excerpt

Centrosome amplification (CA) is a hallmark of cancer, observable in ≥75% of breast tumors. CA drives aggressive cellular phenotypes such as chromosomal instability (CIN) and invasiveness. Thus, assessment of CA may offer insights into the prognosis of breast cancer and identify patients who might benefit from centrosome declustering agents. However, it remains unclear whether CA is correlated with clinical...

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PMID: 28325915
DOI: 10.1038/s41598-017-00363-w

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