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Article

The NRF2 gene variant, -653G/A, is associated with nephritis in childhood-onset systemic lupus erythematosus.

Lupus - 1 Sept 2010

Córdova E J, Velázquez-Cruz R, Centeno F, Baca V, Orozco L

Abstract excerpt

Systemic lupus erythematosus (SLE) is an autoimmune disease associated with oxidative stress and characterized by chronic inflammation. Kidney malfunction, an aggressive characteristic of this disease, is not present in all affected individuals. The Nrf2-Keap1 pathway is important in protecting against oxidative stress and inflammation. Mouse models and genome-wide scans have suggested NRF2 (Nuclear factor...

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Identifiers

PMID: 20507872
DOI: 10.1177/0961203310367917

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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