Article
Neutrophil cytosolic factor 2 (NCF2) gene polymorphism is associated with juvenile-onset systemic lupus erythematosus, but probably not with other autoimmune rheumatic diseases in children.
Molecular genetics & genomic medicine - 1 Jan 2022
Bakutenko Ivan Y, Haurylchyk Irena D, Nikitchenko Natalia V, Sechko Elena V, Kozyro Inna A, Tchitchko Alexei M, Batyan Galina M, Sukalo Alexander V, Ryabokon Nadezhda I
Abstract excerpt
BACKGROUND: Genetic variations of neutrophil cytosolic factor 2 (NCF2), a subunit of NADPH oxidase, are usually associated with chronic granulomatous disease, and their relationship with autoimmune disorders through the defective NADPH oxidase function during phagocytosis is suggested. Our study aimed to explore whether there is an association between the non-synonymous single nucleotide polymorphism in the NCF2...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.