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Single-nucleotide polymorphisms (SNPs) of antioxidant enzymes SOD2 and GSTP1 genes and SLE risk and severity in an Egyptian pediatric population.

Clinical biochemistry - 1 Feb 2021

Abd El Azeem Rania A, Zedan Mohamed M, Saad Entsar A, Mutawi Thuraya M, Attia Zeinab R

Abstract excerpt

BACKGROUND: Systemic lupus erythematosus (SLE) is a chronic autoimmune disease associated with increased oxidative stress that participates in immune dysregulation, and injury resulting in loss of immune tolerance and increased auto-antibody production. This study was designed to investigate the effects of genetic polymorphisms of the antioxidant enzymes genes that code for SOD2 (rs2758332) and GSTP1 (rs1695) on...

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PMID: 33264651
DOI: 10.1016/j.clinbiochem.2020.11.010

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