Article
MBL2 gene variants coding for mannose-binding lectin deficiency are associated with increased risk of nephritis in Danish patients with systemic lupus erythematosus.
Lupus - 1 Oct 2014
Tanha N, Troelsen L, From Hermansen M-L, Kjær L, Faurschou M, Garred P, Jacobsen S
Abstract excerpt
OBJECTIVES: Autoimmunity may in part result from deficiencies in the processing of apoptotic debris. As mannose-binding lectin (MBL) is involved in such processes, we hypothesized that the variants in the MBL2 gene resulting in MBL deficiency confer an increased risk of nephritis in systemic lupus erythematosus (SLE). METHODS: A total of 171 SLE patients attending a Danish tertiary rheumatology referral center...
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