Article
Mutational resistance pattern of HIV type 1 in CD14+ monocytes, CD4+ T cells, and plasma from treated patients.
AIDS research and human retroviruses - 1 Jun 2010
Turriziani Ombretta, Boni Arianna, Falasca Francesca, Graziano Francesca, Bucci Mauro, D'Ettorre Gabriella, Fantauzzi Alessandra, Paoletti Francesca, Massetti Anna Paola, Mezzaroma Ivano, Antonelli Guido
Abstract excerpt
It is necessary to understand the molecular nature of the virus population that persists in cellular reservoirs. To achieve this we planned to characterize the patterns of resistance of HIV-1 in CD14(+) monocytes, CD4(+) T cells, and plasma. Blood samples were collected from 42 patients treated for HIV: 32 were in virological failure and in 10 viremia was undetectable. CD14(+) and CD4(+) T cells were isolated...
Topics
- CD4-Positive T-Lymphocytes
- Drug Resistance, Viral
- Genotype
- HIV Infections
- HIV Protease
- HIV Reverse Transcriptase
- HIV-1
- Humans
- Lipopolysaccharide Receptors
- Monocytes