Article
Divergent distribution of HIV-1 drug-resistant variants on and off antiretroviral therapy.
Antiviral therapy - 1 Dec 2002
Venturi Giulietto, Romano Laura, Carli Tiziana, Corsi Paola, Pippi Luigi, Valensin Pier E, Zazzi Maurizio
Abstract excerpt
OBJECTIVE: To investigate the distribution of drug-resistant HIV-1 variants in plasma RNA and peripheral blood monuclear cell (PBMC) DNA at treatment failure while on therapy and after stopping therapy. DESIGN: Fifty-eight patients failing their first highly active antiretroviral treatment while on therapy and 50 patients after a median of 18.6 weeks after treatment interruption following multiple treatment...
Topics
- Acquired Immunodeficiency Syndrome
- Anti-HIV Agents
- Antiretroviral Therapy, Highly Active
- DNA, Viral
- Drug Resistance, Viral
- Genotype
- HIV-1
- Humans
- Leukocytes, Mononuclear
- Mutation
- RNA, Viral