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Article

Blood monocytes harbor HIV type 1 strains with diversified phenotypes including macrophage-specific CCR5 virus.

The Journal of infectious diseases - 15 Jan 2008

Xu Younong, Zhu Haiying, Wilcox Carrie K, van't Wout Angélique, Andrus Thomas, Llewellyn Nicholas, Stamatatos Leonidas, Mullins James I, Corey Lawrence, Zhu Tuofu

Abstract excerpt

BACKGROUND: Recent studies have shown that blood monocytes harbor human immunodeficiency virus type 1 (HIV-1) variants that are genotypically distinguishable from those in CD4(+) T cells. However, the biological function of monocyte-derived HIV-1 remains unclear. METHODS: Using pseudovirus assay, we analyzed the phenotype conferred by monocyte-derived HIV-1 envelopes from 8 patients. RESULTS: All pseudoviruses...

Read the complete abstract on PubMed

Topics

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Share to CD4-Positive T-Lymphocytes
Share to HIV-1

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to HIV Envelope Protein gp120

Share to HIV Infections

Share to Macrophages

Share to Monocytes

Share to Peptide Fragments

Share to Receptors, CCR5

Source

Identifiers

PMID: 18173363
DOI: 10.1086/524847

Genes

CCR5
CCR3
CXCR4
CCR1
GPR15

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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