Article
Identification and characterization of HIV-1 latent viral reservoirs in peripheral blood.
Journal of clinical microbiology - 1 Jan 2015
Chargin Amanda, Yin Fangfang, Song Min, Subramaniam Srividyabhuvaneswari, Knutson Grace, Patterson Bruce K
Abstract excerpt
Plasma viral load and CD4 counts are effective for clinical monitoring, but they do not give a full representation of HIV-1 quasispecies in cellular reservoirs, the major repository of replication-competent HIV-1 in infected individuals. We sought to develop a diagnostic system that might stimulate the replication-competent HIV-1 reservoirs for enhanced clinical monitoring, including selection of antiretroviral...
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