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Monocyte-derived macrophages contain persistent latent HIV reservoirs

27 Mar 2023

Abstract excerpt

The development of persistent cellular reservoirs of latent human immunodeficiency virus (HIV) is a critical obstacle to viral eradication since viral rebound takes place once anti-retroviral therapy (ART) is interrupted. Previous studies show that HIV persists in myeloid cells (monocytes and macrophages) in blood and tissues in virologically suppressed people with HIV (vsPWH). However, how myeloid cells...

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PMID: 36973419
DOI: 10.1038/s41564-023-01349-3

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