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Article

Disruption of mouse ERCC1 results in a novel repair syndrome with growth failure, nuclear abnormalities and senescence.

Current biology : CB - 1 Jun 1997

Weeda G, Donker I, de Wit J, Morreau H, Janssens R, Vissers C J, Nigg A, van Steeg H, Bootsma D, Hoeijmakers J H

Abstract excerpt

BACKGROUND: The structure-specific ERCC1/XPF endonuclease complex that contains the ERCC1 and XPF subunits is implicated in the repair of two distinct types of lesions in DNA: nucleotide excision repair (NER) for ultraviolet-induced lesions and bulky chemical adducts; and recombination repair of the very genotoxic interstrand cross-links. RESULTS: Here, we present a detailed analysis of two types of mice with...

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Source

Identifiers

PMID: 9197240
DOI: 10.1016/s0960-9822(06)00190-4

Genes

ERCC1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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Disruption of mouse ERCC1 results in a novel repair syndrome with growth failure, nuclear abnormalities and senescence.PMID 9197240Read ↗

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A neurological phenotype in mice with DNA repair gene Ercc1 deficiency.Semantic proximity Read ↗

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Nucleotide excision repair gene (ERCC1) deficiency causes G(2) arrest in hepatocytes and a reduction in liver binucleation: the role of p53 and p21.Semantic proximity Read ↗

Spontaneous DNA damage to the nuclear genome promotes senescence, redox imbalance and agingSemantic proximity Read ↗

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