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Article

Metabotyping of long-lived mice using 1H NMR spectroscopy.

Journal of proteome research - 6 Apr 2012

Wijeyesekera Anisha, Selman Colin, Barton Richard H, Holmes Elaine, Nicholson Jeremy K, Withers Dominic J

Abstract excerpt

Significant advances in understanding aging have been achieved through studying model organisms with extended healthy lifespans. Employing 1H NMR spectroscopy, we characterized the plasma metabolic phenotype (metabotype) of three long-lived murine models: 30% dietary restricted (DR), insulin receptor substrate 1 null (Irs1-/-), and Ames dwarf (Prop1df/df). A panel of metabolic differences were generated for each...

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Identifiers

PMID: 22225495
DOI: 10.1021/pr2010154
PMCID: PMC4467904

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