Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The calmodulin-stimulated adenylate cyclase ADCY8 sets the sensitivity of zebrafish retinal axons to midline repellents and is required for normal midline crossing.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 26 May 2010

Xu Hong, Leinwand Sarah G, Dell Alison L, Fried-Cassorla Emma, Raper Jonathan A

Abstract excerpt

The chemokine SDF1 activates a cAMP-mediated signaling pathway that antagonizes retinal responses to the midline repellent slit. We show that knocking down the calmodulin-activated adenylate cyclase ADCY8 makes retinal axons insensitive to SDF1. Experiments in vivo using male and female zebrafish (Danio rerio) confirm a mutual antagonism between slit signaling and ADCY8-mediated signaling. Unexpectedly, knockdown...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adenylyl Cyclases
Share to Cell Transplantation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Chemokine CXCL12

Share to Chick Embryo

Share to Colforsin

Share to Electroporation

Share to Functional Laterality

Share to Retinal Ganglion Cells

Source

Open in PubMed Open full text

Identifiers

PMID: 20505109
DOI: 10.1523/JNEUROSCI.0699-10.2010
PMCID: PMC2906118

Genes

ADCY8
ADCY1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The calmodulin-stimulated adenylate cyclase ADCY8 sets the sensitivity of zebrafish retinal axons to midline repellents and is required for normal midline crossing.PMID 20505109Read ↗

A Drosophila homolog of cyclase-associated proteins collaborates with the Abl tyrosine kinase to control midline axon pathfinding.Semantic proximity Read ↗

Dscam guides embryonic axons by Netrin-dependent and -independent functions.Semantic proximity Read ↗

Calmodulin and son of sevenless dependent signaling pathways regulate midline crossing of axons in the Drosophila CNS.Semantic proximity Read ↗

Axon guidance at the midline choice point.Semantic proximity Read ↗

Protocadherin-Mediated Cell Repulsion Controls the Central Topography and Efferent Projections of the Abducens NucleusSemantic proximity Read ↗

Flamingo, a seven-pass transmembrane cadherin, cooperates with Netrin/Frazzled in Drosophila midline guidance.Semantic proximity Read ↗

Collective cell migration requires vesicular trafficking for chemoattractant delivery at the trailing edgeSemantic proximity Read ↗

The Drosophila receptor guanylyl cyclase Gyc76C is required for semaphorin-1a-plexin A-mediated axonal repulsion.Semantic proximity Read ↗

A frazzled/DCC-dependent transcriptional switch regulates midline axon guidance.Semantic proximity Read ↗

SEK-1 MAPKK mediates Ca2+ signaling to determine neuronal asymmetric development in Caenorhabditis elegans.Semantic proximity Read ↗

Abelson tyrosine kinase is required to transduce midline repulsive cues.Semantic proximity Read ↗

Cytoplasmic domain requirements for Frazzled-mediated attractive axon turning at the Drosophila midline.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.