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Article

A frazzled/DCC-dependent transcriptional switch regulates midline axon guidance.

Science (New York, N.Y.) - 15 May 2009

Yang Long, Garbe David S, Bashaw Greg J

Abstract excerpt

Precise wiring of the nervous system depends on coordinating the action of conserved families of proteins that direct axons to their appropriate targets. Slit-roundabout repulsion and netrin-deleted in colorectal cancer (DCC) (frazzled) attraction must be tightly regulated to control midline axon guidance in vertebrates and invertebrates, but the mechanism mediating this regulation is poorly defined. Here, we...

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Identifiers

PMID: 19325078
DOI: 10.1126/science.1171320
PMCID: PMC4078765

Genes

DCC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

A frazzled/DCC-dependent transcriptional switch regulates midline axon guidance.PMID 19325078Read ↗

Independent functions of Slit-Robo repulsion and Netrin-Frazzled attraction regulate axon crossing at the midline in Drosophila.Semantic proximity Read ↗

Chimeric axon guidance receptors: the cytoplasmic domains of slit and netrin receptors specify attraction versus repulsion.Semantic proximity Read ↗

Cytoplasmic domain requirements for Frazzled-mediated attractive axon turning at the Drosophila midline.Semantic proximity Read ↗

Flamingo, a seven-pass transmembrane cadherin, cooperates with Netrin/Frazzled in Drosophila midline guidance.Semantic proximity Read ↗

Guidance cues at the Drosophila CNS midline: identification and characterization of two Drosophila Netrin/UNC-6 homologs.Semantic proximity Read ↗

Mushroom body defect is required in parallel to Netrin for midline axon guidance in Drosophila.Semantic proximity Read ↗

RETRACTED: Hierarchical organization of guidance receptors: silencing of netrin attraction by slit through a Robo/DCC receptor complex.Semantic proximity Read ↗

Frazzled cytoplasmic P-motifs are differentially required for axon pathway formation in the Drosophila embryonic CNS.Semantic proximity Read ↗

Draxin Inhibits Axonal Outgrowth through the Netrin Receptor DCCSemantic proximity Read ↗

Dscam guides embryonic axons by Netrin-dependent and -independent functions.Semantic proximity Read ↗

Robo and Frazzled/DCC mediate dendritic guidance at the CNS midline.Semantic proximity Read ↗

Netrin-DCC, Robo-Slit, and heparan sulfate proteoglycans coordinate lateral positioning of longitudinal dopaminergic diencephalospinal axons.Semantic proximity Read ↗

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