Article
Calmodulin and son of sevenless dependent signaling pathways regulate midline crossing of axons in the Drosophila CNS.
Development (Cambridge, England) - 1 May 2000
Fritz J L, VanBerkum M F
Abstract excerpt
The establishment of axon trajectories is ultimately determined by the integration of intracellular signaling pathways. Here, a genetic approach in Drosophila has demonstrated that both Calmodulin and Son of sevenless signaling pathways are used to regulate which axons cross the midline. A loss in either signaling pathway leads to abnormal projection of axons across the midline and these increase with roundabout...
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