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Article

Cytoplasmic domain requirements for Frazzled-mediated attractive axon turning at the Drosophila midline.

Development (Cambridge, England) - 1 Dec 2007

Garbe David S, O'Donnell Mike, Bashaw Greg J

Abstract excerpt

The conserved DCC ligand-receptor pair Netrin and Frazzled (Fra) has a well-established role in axon guidance. However, the specific sequence motifs required for orchestrating downstream signaling events are not well understood. Evidence from vertebrates suggests that P3 is important for transducing Netrin-mediated turning and outgrowth, whereas in C. elegans it was shown that the P1 and P2 conserved sequence...

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Source

Identifiers

PMID: 18003737
DOI: 10.1242/dev.012872

Genes

DCC

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Cytoplasmic domain requirements for Frazzled-mediated attractive axon turning at the Drosophila midline.PMID 18003737Read ↗

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Inhibition of netrin-mediated axon attraction by a receptor protein tyrosine phosphatase.Semantic proximity Read ↗

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