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Article

A Drosophila homolog of cyclase-associated proteins collaborates with the Abl tyrosine kinase to control midline axon pathfinding.

Neuron - 14 Nov 2002

Wills Zachary, Emerson Mark, Rusch Jannette, Bikoff Jay, Baum Buzz, Perrimon Norbert, Van Vactor David

Abstract excerpt

We demonstrate that Drosophila capulet (capt), a homolog of the adenylyl cyclase-associated protein that binds and regulates actin in yeast, associates with Abl in Drosophila cells, suggesting a functional relationship in vivo. We find a robust and specific genetic interaction between capt and Abl at the midline choice point where the growth cone repellent Slit functions to restrict axon crossing. Genetic...

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PMID: 12441051
DOI: 10.1016/s0896-6273(02)01022-x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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