Article
Cytosine arabinoside enhancement of gamma irradiation induced mutations in human T-lymphocytes.
Environmental and molecular mutagenesis - 1 Jan 1991
O'Neill J P, Sullivan L M, Hunter T C, Nicklas J A
Abstract excerpt
The frequency of 6-thioguanine resistant (TGr) mutants induced in human G0 phase T-lymphocytes by 200 cGy of gamma irradiation is greatly enhanced by incubation with cytosine arabinoside (ara-C) after irradiation. The mutant frequency increased with increasing incubation time in ara-C for up to 2...
Topics
- Cells, Cultured
- Chromosome Aberrations
- Cytarabine
- DNA
- DNA Damage
- DNA Repair
- Dose-Response Relationship, Radiation
- Drug Resistance
- Gamma Rays
- Gene Frequency
- Humans
- Mutation
- T-Lymphocytes
- Thioguanine