Article
Molecular analysis of in vivo hprt mutations in human T lymphocytes. V. Effects of total body irradiation secondary to radioimmunoglobulin therapy (RIT)
Mutagenesis - 1 Sept 1990
Nicklas J A, Falta M T, Hunter T C, O'Neill J P, Jacobson-Kram D, Williams J R, Albertini R J
Abstract excerpt
The hprt (hypoxanthine guanine phosphoribosyltransferase) T cell cloning assay was used to detect in vivo mutations in T lymphocytes of individuals receiving radioimmunoglobulin therapy (RIT). A total of 28 patients receiving 131I and/or 90Y-labeled antiferritin antibodies was studied. Mutant fre...
Topics
- Adult
- Aged
- Aged, 80 and over
- Blotting, Southern
- Carcinoma, Hepatocellular
- Gene Rearrangement
- Genes
- Humans
- Hypoxanthine Phosphoribosyltransferase
- Immunotherapy
- Liver Neoplasms
- Middle Aged
- Mutation
- T-Lymphocytes
- Whole-Body Irradiation