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Article

In vitro studies of the genotoxicity of ionizing radiation in human G(0) T lymphocytes.

Environmental and molecular mutagenesis - 1 Dec 2005

O'Neill Patrick, Nicklas Janice, Hirsch Betsy, Jostes Rick, Hunter Timothy, Sullivan Linda, Albertini Richard

Abstract excerpt

In an effort to mimic human in vivo exposures to ionizing irradiation, G(0) phase T lymphocytes from human peripheral blood samples were utilized for in vitro studies of the genotoxic effects of (137)Cs low-LET irradiation and (222)Rn high-LET irradiation. Both types of radiation induced mutations in the HPRT gene in a dose-dependent manner, with a mutant frequency (MF) = 4.28 + 1.34x + 7.51x(2) for (137)Cs (R(2)...

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Identifiers

PMID: 15887213
DOI: 10.1002/em.20143

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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