Article
Phenotypic alterations of dendritic cells are involved in suppressive activity of trichosanthin-induced CD8+CD28- regulatory T cells.
Journal of immunology (Baltimore, Md. : 1950) - 1 Jul 2010
Wang Baolong, Jiao Zhijun, Shao Xiaoyi, Lu Liming, Yang Neng, Zhou Xiaorong, Xin Lijun, Zhou Yun, Chou Kuang-Yen
Abstract excerpt
The nature and differentiation of regulatory CD8(+)CD28(-) T cells are poorly understood. In this study, we demonstrate that native Ag trichosanthin (Tk), a highly purified linear peptide isolated from a Chinese medicinal herb, is able to induce strong suppression of OVA-specific lymphoproliferation at low concentrations via activation of IL-4/IL-10-secreting CD8(+)CD28(-) regulatory T cells (Tregs). To elucidate...
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