Article
Allergic TH2 Response Governed by B-Cell Lymphoma 6 Function in Naturally Occurring Memory Phenotype CD4+ T Cells.
Frontiers in immunology - 1 Jan 2018
Ogasawara Takashi, Kohashi Yuko, Ikari Jun, Taniguchi Toshibumi, Tsuruoka Nobuhide, Watanabe-Takano Haruko, Fujimura Lisa, Sakamoto Akemi, Hatano Masahiko, Hirata Hirokuni, Fukushima Yasutsugu, Fukuda Takeshi, Kurasawa Kazuhiro, Tatsumi Koichiro, Tokuhisa Takeshi, Arima Masafumi
Abstract excerpt
Transcriptional repressor B-cell lymphoma 6 (Bcl6) appears to regulate TH2 immune responses in allergies, but its precise role is unclear. We previously reported that Bcl6 suppressed IL-4 production in naïve CD4+ T cell-derived memory TH2 cells. To investigate Bcl6 function in allergic responses in naturally occurring memory phenotype CD4+ T (MPT) cells and their derived TH2 (MPTH2) cells, Bcl6-manipulated mice,...
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