Article
Innate profiles of cytokines implicated on oral tolerance correlate with low- or high-suppression of humoral response.
Immunology - 1 Jul 2010
Silva Maria F, Kamphorst Alice O, Hayashi Elize A, Bellio Maria, Carvalho Claudia R, Faria Ana M C, Sabino Kátia C C, Coelho Marsen G P, Nobrega Alberto, Tavares Daniel, Silva Antonio C
Abstract excerpt
SUMMARY: Oral tolerance (OT) is being studied with great interest because of its therapeutic potential in allergy and autoimmunity. In the present study, two mouse strains with extreme phenotypes of OT susceptibility (TS) or resistance (TR) to ovalbumin (OVA) were used to demonstrate whether the tr and ts genes, cumulated during 18 generations of bi-directional genetic selection, influence expression of...
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