Article
An exhausted phenotype of TH 2 cells is primed by allergen exposure, but not reinforced by allergen-specific immunotherapy.
Allergy - 1 Sept 2021
Wang Shu-Hung, Zissler Ulrich M, Buettner Maren, Heine Sonja, Heldner Alexander, Kotz Sebastian, Pechtold Lisa, Kau Josephine, Plaschke Mirjam, Ullmann Julia T, Guerth Ferdinand, Oelsner Madlen, Alessandrini Francesca, Blank Simon, Chaker Adam M, Schmidt-Weber Carsten B, Jakwerth Constanze A
Abstract excerpt
BACKGROUND: Studies show that proallergic TH 2 cells decrease after successful allergen-specific immunotherapy (AIT). It is likely that iatrogenic administration of allergens drives these cells to exhaustion due to chronic T-cell receptor stimulation. This study aimed to investigate the exhaustion of T cells in connection with allergen exposure during AIT in mice and two independent patient cohorts. METHODS:...
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