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Article

Regulatory T cell reprogramming toward a Th2-cell-like lineage impairs oral tolerance and promotes food allergy.

Immunity - 17 Mar 2015

Noval Rivas Magali, Burton Oliver T, Wise Petra, Charbonnier Louis-Marie, Georgiev Peter, Oettgen Hans C, Rachid Rima, Chatila Talal A

Abstract excerpt

Oral immunotherapy has had limited success in establishing tolerance in food allergy, reflecting failure to elicit an effective regulatory T (Treg) cell response. We show that disease-susceptible (Il4ra(F709)) mice with enhanced interleukin-4 receptor (IL-4R) signaling exhibited STAT6-dependent impaired generation and function of mucosal allergen-specific Treg cells. This failure was associated with the...

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Source

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Identifiers

PMID: 25769611
DOI: 10.1016/j.immuni.2015.02.004
PMCID: PMC4366316

Genes

STAT6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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