Article
The BpeAB-OprB efflux pump of Burkholderia pseudomallei 1026b does not play a role in quorum sensing, virulence factor production, or extrusion of aminoglycosides but is a broad-spectrum drug efflux system.
Antimicrobial agents and chemotherapy - 1 Aug 2010
Mima Takehiko, Schweizer Herbert P
Abstract excerpt
Most Burkholderia pseudomallei strains are intrinsically aminoglycoside resistant, mainly due to AmrAB-OprA-mediated efflux. Rare naturally occurring or genetically engineered mutants lacking this pump are aminoglycoside susceptible despite the fact that they also encode and express BpeAB-OprB, which was reported to mediate efflux of aminoglycosides in the Singapore strain KHW. To reassess the role of BpeAB-OprB...
Topics
- Aminoglycosides
- Anti-Bacterial Agents
- Bacterial Outer Membrane Proteins
- Burkholderia pseudomallei
- Culture Media
- Drug Resistance, Multiple, Bacterial
- Humans
- Membrane Transport Proteins
- Microbial Sensitivity Tests