Article
BpeAB-OprB, a multidrug efflux pump in Burkholderia pseudomallei.
Antimicrobial agents and chemotherapy - 1 Apr 2004
Chan Y Y, Tan T M C, Ong Y M, Chua K L
Abstract excerpt
Burkholderia pseudomallei, the causative agent of melioidosis, is intrinsically resistant to a wide range of antimicrobial agents, including beta-lactams, aminoglycosides, macrolides, and polymyxins. An operon, bpeR-bpeA-bpeB-oprB, which encodes a putative repressor, a membrane fusion protein, an inner membrane protein, and an outer membrane protein, respectively, of a multidrug efflux pump of the...
Topics
- Aminoglycosides
- Anti-Bacterial Agents
- Bacterial Outer Membrane Proteins
- Burkholderia pseudomallei
- Carrier Proteins
- DNA Primers
- DNA, Bacterial
- Dipeptides
- Drug Resistance, Multiple, Bacterial
- Erythromycin
- Gene Deletion